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Abstract #0424

Q-space trajectory imaging (QTI): Enhanced specificity in diffusion MRI characterisation of hypertrophic mouse hearts ex vivo

Maryam Afzali1,2, Samo Lasič3,4, Henrik Lundell3,5, Leah Khazin1, Richard J. Foster1, Sam Coveney1, Sven Plein1, Erica Dall'Armellina1, Nadira Y. Yuldasheva1, Filip Szczepankiewicz6, Jürgen E. Schneider1, and Irvin Teh1
1Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 2Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 3Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark, 4Department of Diagnostic Radiology, Lund University, Lund, Sweden, 5MR Section, DTU Health Tech, Technical University of Denmark, Lyngby, Denmark, 6Medical Radiation Physics, Clinical Sciences Lund, Lund University, Lund, Sweden

Synopsis

Keywords: Myocardium, Diffusion Modeling, cardiac microstructure, tensor-valued encoding, b-tensor encoding, aortic stenosis, hypertrophic cardiomyopathy

Motivation: Adverse remodelling following aortic stenosis may be characterised by cardiomyocyte hypertrophy, disarray and/or increased fibrosis. Existing methods lack the specificity to distinguish between these features. Q-Space trajectory imaging (QTI) may help to overcome this limitation.

Goal(s): To investigate the potential value of QTI in microstructural characterisation of hypertrophic hearts.

Approach: QTI data were acquired and analysed in control and hypertrophic mouse hearts ex vivo.

Results: Hypertrophic hearts exhibited higher mean diffusivity, and lower fractional anisotropy (FA), microscopic FA and anisotropic and total mean kurtosis relative to controls. This points primarily to cardiomyocyte hypertrophy rather than cell disarray or fibrosis.

Impact: Q-space trajectory imaging has the potential to distinguish different microstructural features including cardiomyocyte hypertrophy, disarray and/or increased fibrosis seen in aortic stenosis and other pathologies, with greater specificity than existing techniques, and could lead to improved diagnosis and patient management.

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Keywords