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Abstract #0425

Early Myocardial Dysfunction in Sepsis Patients: Insights from Creatine CEST CMR Imaging

Quanying Xu1, Ke Xue2, Yuxin Yang2, and Ting Liu1
1The First Hospital of China Medical University, Shenyang, China, 2United Imaging Research Institute of Intelligent Imaging, Beijing, China

Synopsis

Keywords: Myocardium, Cardiomyopathy

Motivation: Myocardial dysfunction is a common complication of sepsis, and a leading cause of mortality. However, research on assessing myocardial dysfunction in sepsis remains limited.

Goal(s): To explore the efficacy of chemical exchange saturation transfer (CEST) for evaluating myocardial dysfunction in patients with sepsis.

Approach: We applied CMR to quantitatively evaluate the myocardial tissue characteristics and cardiac function in patients and healthy controls (HCs) by T1, T2, cine and CEST mapping.

Results: Patients exhibited significantly reduced creatine level, elevated T1 and T2, lower LVEF and RVEF compared to HCs. cTn-I>0.026ng/ml was associated with decreased Cr-CEST value.

Impact: CEST can complement conventional CMR by providing valuable insights into early clinical diagnosis of myocardial dysfunction in sepsis, thereby facilitating timely therapeutic strategies.

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