Abstract #0434
Understanding Resilience and White Matter Damage in mTBI: Predictive Insights from Diffusion MRI and Blood Biomarkers
Melissa Gabriella Papini1,2,3,4, Jacinta Thorne5,6, Aleksandra Gozt6,7, Andre Avila1,6,7, Caerwen Ellery1,6,7, Ruby Gilroy1,6, Geena Gill8, Francesca Buhagiar9, Elizabeth Thomas10, Amanda Jefferson11, Carmela Pestell7,9, Alexander Ring12,13, Glenn Arendts14,15, John Charles Iliff16,17,18,19, Antonio Celenza20,21, Sjinene Van Schalkwyk22, Philip Brooks16,23,24, Dan Xu6,24,25, Stephen Honeybul15,18,20,26, Gill Cowen1,7, Daniel Fatovich18,21,27, Ben Smedley23, Ashes Mukherjee28, Michael Bynevelt20, Melinda Fitzgerald6,7, and Sarah Hellewell6,7
1Curtin Medical School, Curtin University, Nedlands, Australia, 2Faculty of Health Sciences, Curtin Health Innovation Research Institute, Bentley, Australia, 3Perron Institute of Neurological and Translational Science, Nedlands, Australia, 4Curtin Medical School, Perth, Australia, 5Curtin Health Innovation Research Institute, Curtin University, Perth, Australia, 6Perron Institute of Neurological and Translational Science, Perth, Australia, 7Curtin Health Innovation Research Institute, Perth, Australia, 8Curtin Health Innovation Research Institute, Curtin University, Nedlands, Australia, 9School of Psychological Science, The University of Western Australia, Perth, Australia, 10Curtin School of Population Health, Curtin University, Perth, Australia, 11Curtin Medical School, Curtin University, Perth, Australia, 12Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Australia, 13School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia, 14Harry Perkins Research Institute, Perth, Australia, 15Fiona Stanley Hospital, Perth, Australia, 16Saint John of God Midland Public Hospital, Perth, Australia, 17Saint John of God Hospital Murdoch, Perth, Australia, 18Royal Perth Hospital, Perth, Australia, 19Royal Flying Doctor Service- Western Operations, Perth, Australia, 20Sir Charles Gairdner Hospital, Perth, Australia, 21The University of Western Australia, Perth, Australia, 22Joondalup Health Campus, Perth, Australia, 23Rockingham General Hospital, Perth, Australia, 24The University of Notre Dame, Perth, Australia, 25Sun Yat-Sen University, Guangzhou, China, 26Department of Health, Government of Western Australia, Perth, Australia, 27Harry Perkins Institute of Medical Research, Perth, Australia, 28Armadale Health Service, Perth, Australia
Synopsis
Keywords: Traumatic Brain Injury, White Matter
Motivation: This research addresses the need for accurate mTBI diagnostics by combining diffusion MRI and blood biomarkers, aiming to improve early detection and enable targeted interventions to support recovery in high-risk patients.
Goal(s): This study aims to assess relationships between dMRI metrics and blood-based white matter biomarkers in a diverse cohort, evaluate their predictive capacity for PPCS development, and examine the role of psychological resilience in influencing these biomarkers and recovery outcomes.
Approach: Longitudinal cohort study with participants undergoing dMRI, blood biomarker analysis, and resilience assessment. Statistical models will evaluate biomarker predictive power and resilience effects on white matter damage and PPCS progression.
Impact: Establishing a relationship between dMRI metrics and blood-based biomarkers in a real-world mTBI population could enhance understanding of white matter pathophysiology and support prognostic clinical tool development. Insights into resilience may enable early identification of high-risk patients needing targeted intervention.
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