Abstract #0448

Susceptibility components from DECOMPOSE-QSM reveal dopaminergic and nigrostriatal degeneration in prodromal alpha-synucleinopathies

Oliver C. Kiersnowski¹, Pietro Mattioli^1,2, Lucia Argenti^1,2, Laura Avanzino^1,2, Francesco Calizzano², Andrea Diociasi¹, Laura Falcitano¹, Mattia Losa², Federico Massa^1,2, Silvia D. Morbelli³, Beatrice Orso², Elisa Pelosin^1,2, Stefano Raffa¹, Chunlei Liu⁴, Matteo Pardini^1,2, Dario Arnaldi^1,2, Luca Roccatagliata^1,2, and Mauro Costagli^1,2

¹IRCCS Ospedale Policlinico San Martino, Genoa, Italy, ²University of Genoa, Genoa, Italy, ³University of Turin, Turin, Italy, ⁴University of California, Berkeley, CA, United States

Synopsis

Keywords: Parkinson's Disease, Quantitative Susceptibility mapping

Motivation: To assess neurodegeneration in prodromal-to-overt alpha-synucleinopathies with a non-invasive MRI examination.

Goal(s): To investigate whether MRI-based paramagnetic and diamagnetic susceptibility components can assess dopaminergic and nigrostriatal degeneration.

Approach: DECOMPOSE-QSM was used to identify susceptibility component changes in prodromal and overt alpha-synucleinopathies. Correlations between susceptibility components and single photon emission tomography (SPECT)-scores were investigated.

Results: Substantia nigra iron accumulation occurs in prodromal alpha-synucleinopathies alongside dopaminergic pathway degeneration identified by SPECT. Substantia nigra paramagnetic component susceptibility and putamen diamagnetic component susceptibility correlate with dopaminergic pathway degeneration.

Impact: Paramagnetic and diamagnetic component susceptibility correlate with DaT-SPECT Z-scores in the substantia nigra and putamen. Source-separated magnetic susceptibility holds promise as a biomarker for assessing the degeneration of the nigrostriatal dopaminergic pathway, key for evaluating prodromal and overt alpha-synucleinopathies.

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