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Abstract #0449

Diurnal regulation of cerebrospinal fluid flow dynamics assessed using cardiac-corrected phase-contrast magnetic resonance imaging

Melanie Leguizamon1, Kilian Hett1, Maeve Curtin1, Abbey DuBois1, Alexander K. Song1, Caleb Han1, Maria Garza1, Paula Trujillo1, Colin D. McKnight2, Ciaran M. Considine1, and Manus J. Donahue1,3
1Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 2Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Neurofluids, Neurofluids, cerebrospinal fluid, phase-contrast magnetic resonance imaging, circadian rhythm

Motivation: Circadian regulation of cerebrospinal fluid (CSF) flow dynamics during wakefulness is incompletely understood yet has relevance to the growing number of studies of neurofluid circulation dysfunction.

Goal(s): To investigate repeated changes in CSF flow kinetics through the cerebral aqueduct over the time of day.

Approach: In healthy adults, phase-contrast-MRI was repeated four times over the circadian cycle of wakefulness to obtain measures of CSF flux and velocity, which were contrasted with time of day.

Results: Larger diastolic, retrograde flux and larger systolic, anterograde flux was observed from morning to afternoon, suggesting CSF flow becomes more hyperdynamic later in the day.

Impact: This works provides new evidence in humans that CSF flow dynamics at the level of the cerebral aqueduct become more dynamic over the circadian rhythm of wakefulness, with a directionality similar to that observed with increasing age and neurodegeneration.

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Keywords