Keywords: Neurofluids, Neurofluids, cerebrospinal fluid, phase-contrast magnetic resonance imaging, circadian rhythm
Motivation: Circadian regulation of cerebrospinal fluid (CSF) flow dynamics during wakefulness is incompletely understood yet has relevance to the growing number of studies of neurofluid circulation dysfunction.
Goal(s): To investigate repeated changes in CSF flow kinetics through the cerebral aqueduct over the time of day.
Approach: In healthy adults, phase-contrast-MRI was repeated four times over the circadian cycle of wakefulness to obtain measures of CSF flux and velocity, which were contrasted with time of day.
Results: Larger diastolic, retrograde flux and larger systolic, anterograde flux was observed from morning to afternoon, suggesting CSF flow becomes more hyperdynamic later in the day.
Impact: This works provides new evidence in humans that CSF flow dynamics at the level of the cerebral aqueduct become more dynamic over the circadian rhythm of wakefulness, with a directionality similar to that observed with increasing age and neurodegeneration.
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