Keywords: Diffusion Analysis & Visualization, Diffusion Analysis and Visualization, iNPH, Neurofluids, Fluctuation, DNB, Delta-ADC
Motivation: To further advance the analysis of temporal changes in the apparent diffusion coefficient in normal pressure hydrocephalus (iNPH).
Goal(s): To establish a fluctuation magnetic resonance imaging (MRI), we applied dynamical network biomarker (DNB) analysis.
Approach: We assessed diffusion MRI-derived DNB index (dMRI-DNB index) in iNPH.
Results: The dMRI-DNB index in the frontal white matter was significantly higher in the iNPH compared with the control group.
Impact: We establish the basis of DNB-MRI and its clinical application to iNPH. The dMRI-DNB index enables to assess fluctuation of the water molecule in the brain.
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