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Abstract #0456

Modulating cerebrospinal fluid dynamics using pulsed photobiomodulation: the dose and skin-colour dependence

Ariel Motsenyat1,2, Xiaole Zachary Zhong1,3, Hannah Van Lankveld1,2, Joanna X. Chen1,2, and J. Jean Chen1,2,3
1Rotman Research Institute, Baycrest, Toronto, ON, Canada, 2Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada, 3Medical Biophysics, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Neurofluids, Neurodegeneration, Stimulation, Photobiomodulation, Glymphatic System

Motivation: The use of photobiomodulation (PBM) to enhance glymphatic drainage and thus neurotoxic waste clearance, makes it a promising therapeutic tool against neurodegenerative diseases like Alzheimer’s.

Goal(s): This study investigates whether PBM can modulate cerebrospinal fluid (CSF) flow in healthy young adults.

Approach: Adjusting key parameters like wavelength, frequency, and power will determine the most effective PBM protocol.

Results: Our data demonstrates 4 min of PBM-induced increases in CSF flow, greater for higher power density, lower wavelength and pulsation frequency. Intranasal PBM achieved similar performance as transcranial PBM, albeit with 1/20 the power. Participant melanin levels also impact PBM’s effect on CSF flow.

Impact: Photobiomodulation (PBM) has shown to enhance glymphatic drainage by modulating CSF flow, but in a delivery and dose-dependent manner. The significant wavelength-frequency interactions and melanin effects demonstrate the need to optimize PBM delivery in different settings.

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Keywords