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Abstract #0457

Simultaneous assessment of cerebral arterial, venous, and CSF flow dynamics using multiband dual-VENC phase-contrast MRI

Jianing Tang1,2, Zhitao Li1, Tianrui Zhao1,2, Sang Hun Chung1, and Lirong Yan1,2
1Department of Radiology, Northwestern University, Chicago, IL, United States, 2Department of Biomedical Engineering, Northwestern University, Chicago, IL, United States

Synopsis

Keywords: Neurofluids, Neurofluids

Motivation: Blood-neurofluid-coupling plays an important role in maintaining brain’s health and function. However, conventional 2D PC-MRI requires multiple separate scans to image blood and CSF dynamics, which is time-inefficient and sensitive to inter-scan heartbeat variability and physiological movements.

Goal(s): To develop a multi-band dual-VENC PC-MRI (MB-DV PC-MRI) to simultaneously measure CSF, arterial, and venous dynamics within a short scan.

Approach: MB-DV PC-MRI sequence was designed by integrating multi-band RF and dual-VENC into 2D PC-MRI sequence acquisition.

Results: Flow waveforms and hemodynamic measures of arteries, veins, and CSF at different levels were successfully depicted by MB-DV PC-MRI, matching closely with those by multi-scan 2D PC-MRI.

Impact: MD-DV PC-MRI enables simultaneously assessing CSF, arterial, and venous dynamics at multiple segments in the brain within a short scan time, which could be a potentially useful MRI technique to study blood-neurofluid coupling in both cerebrovascular and neurodegenerative diseases.

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Keywords