Meeting Banner
Abstract #0464

Assessing Glymphatic Dynamics in the Human Brain Using Cardiac-Gated diffusion MRI at Ultra-High Field

Ibtisam Aslam1,2, Tommaso Pavan1, Arthur Spencer1, Roberto Martuzzi3, Federica Ribaldi2, Giovanni Frisoni2, and Ileana Jelescu1
1Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL) Lausanne, Lausanne, Switzerland, 2Geneva Memory Centre, Geneva University Hospitals (HUG), Geneva, Switzerland, 3Fondation Campus Biotech Genève, Geneva, Switzerland

Synopsis

Keywords: Neurofluids, IVIM, Glymphatic flow, Cardiac Gating : Perivascular spaces (PVS), DTI-ALPS, High‐Field MRI

Motivation: The glymphatic system is a perivascular network of thin vessels, vital for brain waste clearance, influencing neurological health.

Goal(s): This study investigates the effects of the cardiac cycle, echo times, and b-values on glymphatic flow quantification using diffusion MRI at ultra-high field.

Approach: We measured diffusion along (D||) and perpendicular (D⊥) to the perivascular spaces during systole and diastole at different echo times, and b-values to assess glymphatic dynamics.

Results: Our findings show that D* is higher during systole, especially at lower b-values, indicating that the IVIM regime with cardiac gating is better suited for quantifying glymphatic flow.

Impact: This study shows how glymphatic flow quantification using diffusion MRI in the human brain is influenced by the cardiac cycle, echo time and b-value, paving the way for the non-invasive assessment of glymphatic flow in clinical practice.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords