Keywords: Neurofluids, IVIM, Glymphatic flow, Cardiac Gating : Perivascular spaces (PVS), DTI-ALPS, High‐Field MRI
Motivation: The glymphatic system is a perivascular network of thin vessels, vital for brain waste clearance, influencing neurological health.
Goal(s): This study investigates the effects of the cardiac cycle, echo times, and b-values on glymphatic flow quantification using diffusion MRI at ultra-high field.
Approach: We measured diffusion along (D||) and perpendicular (D⊥) to the perivascular spaces during systole and diastole at different echo times, and b-values to assess glymphatic dynamics.
Results: Our findings show that D* is higher during systole, especially at lower b-values, indicating that the IVIM regime with cardiac gating is better suited for quantifying glymphatic flow.
Impact: This study shows how glymphatic flow quantification using diffusion MRI in the human brain is influenced by the cardiac cycle, echo time and b-value, paving the way for the non-invasive assessment of glymphatic flow in clinical practice.
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