Keywords: Other Neurodegeneration, Neurodegeneration, cognitive impairment
Motivation: Cognitive impairment in dialysis patients may be linked to decreased neurovascular coupling (NVC) and glymphatic system dysfunction. However, their relationship remains unclear.
Goal(s): To investigate the interactions between NVC and glymphatic system function in dialysis patients compared to healthy controls.
Approach: We assessed neurovascular coupling using the ALFF-CBF coupling coefficient and evaluated glymphatic system function through the DTI-ALPS index in 56 peritoneal dialysis patients, 54 hemodialysis patients, and 52 healthy controls.
Results: Dialysis patients exhibited reduced NVC and glymphatic function. However, a significant correlation between neurovascular decoupling and glymphatic dysfunction was consistently observed in dialysis groups.
Impact: This research highlights critical interactions between neurovascular coupling and glymphatic system function, providing insights that could inform therapeutic strategies for cognitive impairment in dialysis patients.
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