Abstract #0499

Connectome-based growth models reveal individual heterogeneity and neurophysiological subtypes of subthreshold depression

Xiaoyi Sun¹, Guanmao Chen², Pan Chen², Xuan Bu¹, Zhangzhang Qi², Shu Zhang², Chao Chen², Zixuan Guo², Xinyue Tang², Ruoyi Chen², Xiaoqin Wang³, Dongtao Wei³, Yuan Chen⁴, Bangshan Liu⁵, Chu-Chung Huang⁶, Yanting Zheng⁷, Yankun Wu⁸, Taolin Chen⁹, Yuqi Cheng¹⁰, Xiufeng Xu¹⁰, Qiyong Gong⁹, Tianmei Si⁸, Shijun Qiu⁷, Ching-Po Lin¹¹, Jingliang Cheng⁴, Yanqing Tang¹², Fei Wang¹², Jiang Qiu³, Peng Xie¹³, Lingjiang Li⁵, Yong He¹, Qian Tao², Mingrui Xia¹, and Ying Wang²

¹Beijing Normal University, Beijing, China, ²Jinan University, Guangzhou, China, ³Southwest University, Chongqing, China, ⁴The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ⁵The Second Xiangya Hospital of Central South University, Changsha, China, ⁶East China Normal University, Shanghai, China, ⁷The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China, ⁸Peking University Sixth Hospital, Beijing, China, ⁹West China Hospital, Sichuan University, Chengdu, China, ¹⁰First Affiliated Hospital of Kunming Medical University, Kunming, China, ¹¹National Yang-Ming Chiao-Tung University, Taipei, Taiwan, ¹²The First Affiliated Hospital of China Medical University, Shenyang, China, ¹³The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Synopsis

Keywords: Functional Connectivity, Brain Connectivity, Depression

Motivation: Subthreshold depression (StD) poses a high risk for major depressive disorder and exhibits substantial clinical heterogeneity. However, the neurobiological substrates underlying this heterogeneity remain largely unknown.

Goal(s): Quantitatively assess the heterogeneity in individual functional connectome abnormalities in StD, and based on this, identify distinct neurophysiological subtypes.

Approach: We constructed normative models of the functional connectome to identify individual deviations and determine subtypes in StD.

Results: StD participants showed remarkable heterogeneity in individual deviations, leading to the identification of two subtypes. These subtypes exhibit differences in brain deviation patterns, depressive symptoms, gene expression profiles, and treatment responses.

Impact: The findings provide valuable insights into the understanding of heterogeneous clinical forms of StD and offer promising implications for future precise diagnosis and treatment of this condition.

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