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Abstract #0500

Functional Connectivity Subtypes in Major Depressive Disorder: Insights Into Connection Patterns and Neurobiological Mechanisms

Haoran Li1, Qian Li1, Fenghua Long1, Yufei Chen1, Yitian Wang1, Beisheng Yang1, Qiyong Gong1, and Fei Li1
1Department of Radiology, Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China

Synopsis

Keywords: Psychiatric Disorders, fMRI (resting state)

Motivation: Major depressive disorder (MDD) is heterogeneous with underlying mechanisms insufficiently studied. Subtyping can help address this heterogeneity.

Goal(s): To identify specific MDD subtypes and their representative brain regions (epicenters) based on brain functional connectivity (FC) alterations, and investigate their biological mechanisms.

Approach: Consensus clustering was applied for subtyping MDD patients. A regression model and correlation analyses with genetic/neurotransmitter profiles were used to quantify FC alterations and explore underlying biological mechanisms, respectively.

Results: Two stable subtypes emerged, exhibiting divergent overall FC patterns with shared and unique epicenters in crucial brain networks, along with shared and varied genetic and neurotransmitter associations.

Impact: The present study suggested the presence of two distinct FC-based subtypes in MDD characterized by shared and different epicenters and biological basis, and enhanced the understanding of MDD heterogeneity.

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