Keywords: Psychiatric Disorders, fMRI (resting state)
Motivation: Major depressive disorder (MDD) is heterogeneous with underlying mechanisms insufficiently studied. Subtyping can help address this heterogeneity.
Goal(s): To identify specific MDD subtypes and their representative brain regions (epicenters) based on brain functional connectivity (FC) alterations, and investigate their biological mechanisms.
Approach: Consensus clustering was applied for subtyping MDD patients. A regression model and correlation analyses with genetic/neurotransmitter profiles were used to quantify FC alterations and explore underlying biological mechanisms, respectively.
Results: Two stable subtypes emerged, exhibiting divergent overall FC patterns with shared and unique epicenters in crucial brain networks, along with shared and varied genetic and neurotransmitter associations.
Impact: The present study suggested the presence of two distinct FC-based subtypes in MDD characterized by shared and different epicenters and biological basis, and enhanced the understanding of MDD heterogeneity.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords