Abstract #0501

Revealing Dynamic Brain Networks in ADHD using Hyperband Resting-State fMRI

Ric John Laboa Ombid¹, Paul Condron², Gil Newburn², Alan Wang^1,3, Hesamoddin Jahanian⁴, Karen Waldie^5,6, Samantha Holdsworth^2,3,5, and Justin Fernandez^1,2,7

¹Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, ²Mātai Medical Research Institute, Gisborne, New Zealand, ³Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, ⁴University of Washington, Seattle, WA, United States, ⁵Centre for Brain Research, University of Auckland, Auckland, New Zealand, ⁶Faculty of Science, University of Auckland, Auckland, New Zealand, ⁷Department of Engineering Science and Biomedical Engineering, Faculty of Engineering, University of Auckland, Auckland, New Zealand

Synopsis

Keywords: fMRI Analysis, fMRI Analysis, ADHD, Hyperband fMRI, dynamic analysis

Motivation: Functional MRI (fMRI) typically employs long repetition times (TR), limiting its ability to capture rapid brain state transitions crucial for understanding dynamic functional connectivity (dFC).

Goal(s): This study aims to improve dFC analysis by using higher temporal resolution Hyperband fMRI.

Approach: We employed Hyperband fMRI (TR = 0.43s) to examine dynamic network engagement in neurotypical (NT) and Attention-Deficit Hyperactivity Disorder (ADHD) participants across two independent brain atlases: Power and Shaefer.

Results: Hyperband fMRI revealed significant dFC differences in ADHD participants with extended engagement in integrated brain states across two independent atlases, demonstrating consistent and robust results.

Impact: Hyperband fMRI with shorter TR demonstrated significant differences in dFC in ADHD. ADHD participants exhibited prolonged engagement, compared with NT, in integrated brain states across two brain atlases, demonstrating efficacy in detecting dynamic neural alterations.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.