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Abstract #0502

Disruption of the gut microbiota-inflammation-brain axis in unmedicated bipolar disorder II depression

Zixuan Guo1, Wei Cui2, and Ying Wang1
1First Affiliated Hospital of Jinan University, Guangzhou, China, 2GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: fMRI Analysis, Psychiatric Disorders

Motivation: The relationships of the gut microbiota-inflammation-brain axis in depressive bipolar disorder (BD) remains under-elaborated.

Goal(s): To investigate relationships of the gut microbiota-inflammation-brain axis in BD.

Approach: To explore the mechanisms underlying the collaborative interaction among brain dysfunction, gut microbiota changes, and inflammation and immune dysregulation in BD II depression.

Results: The current study identified disrupted spontaneous activity and connectivity in cerebellar-DMN in patients with unmedicated BD II depression. Increased intestinal proinflammatory bacteria, and Glu and GABA metabolism related bacteria, as well as elevated serum pro- and anti-inflammatory cytokines were also found in BD II depression.

Impact: The findings bridged a gap in the underlying pathophysiological mechanism of the gut microbiota-inflammation-brain axis in BD II depression.

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