Keywords: fMRI Analysis, Psychiatric Disorders
Motivation: The relationships of the gut microbiota-inflammation-brain axis in depressive bipolar disorder (BD) remains under-elaborated.
Goal(s): To investigate relationships of the gut microbiota-inflammation-brain axis in BD.
Approach: To explore the mechanisms underlying the collaborative interaction among brain dysfunction, gut microbiota changes, and inflammation and immune dysregulation in BD II depression.
Results: The current study identified disrupted spontaneous activity and connectivity in cerebellar-DMN in patients with unmedicated BD II depression. Increased intestinal proinflammatory bacteria, and Glu and GABA metabolism related bacteria, as well as elevated serum pro- and anti-inflammatory cytokines were also found in BD II depression.
Impact: The findings bridged a gap in the underlying pathophysiological mechanism of the gut microbiota-inflammation-brain axis in BD II depression.
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