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Abstract #0508

387μm isotropic resolution in-vivo diffusion MRI using Romer-EPTI on Connectome 2.0 scanner

Fuyixue Wang1,2, Jian Wu1,2, Timothy G. Reese1,2, Hong-Hsi Lee1,2, Bruce R. Rosen1,2,3, Susie Y. Huang1,2,3, Lawrence L. Wald1,2,3, and Zijing Dong1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Diffusion Acquisition, Diffusion Acquisition, Mesoscale, high performance

Motivation: High-resolution diffusion MRI reveals human brain’s fine-scale structure/connectivity.

Goal(s): We aim to push the limit of spatial resolution for in-vivo human dMRI.

Approach: An integrated approach leveraging state-of-the-art acquisition/reconstruction, hardware and correction techniques is employed to enable ultra-high-resolution dMRI. First, a recently developed Romer-EPTI acquisition is employed to obtain SNR gain while achieving distortion-free motion-robust dMRI. Second, Connectome-2.0 scanner with ultra-high-gradient performance further boosts SNR through shortened TE and echo-spacings. Third, correction techniques are proposed and integrated into EPTI reconstruction to address strong concomitant and eddy-current fields caused by strong gradients.

Results: We achieved distortion-free in-vivo mesoscale dMRI at an unprecedented 387um-iso resolution.

Impact: We achieved in-vivo dMRI at 387-um-isotropic resolution with whole-brain coverage by leveraging SNR-efficient distortion-free Romer-EPTI acquisition, ultra-high-gradient-performance Connectome 2.0 scanner, and correction techniques that address strong concomitant and eddy-current fields caused by the strong gradients.

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Keywords