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Abstract #0543

Variability in 13C MRS Measurement of Liver Glycogen in Children.

Abi Spicer1, Penny Anne Gowland1,2, Susan T Francis1,2, Elizabeth J Simpson2,3, Ian Macdonald3, and Stephen Bawden1,2
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2NIHR Nottingham Biomedical Research Centre, Hospital NHS Trust and University of Nottingham, Nottingham, United Kingdom, 3David Greenfield Human Physiology Unit, MRC/ARUK Centre for Musculoskeletal Ageing Research,, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Liver, Spectroscopy, Multinuclear, Carbon-13, Paediatric, Reproducibility, X-nuclei

Motivation: Liver glycogen measures can indicate altered metabolism in disorders which impact the health of children. MRS techniques offer a non-invasive method to assess liver glycogen in vivo, but there is a need to demonstrate such measures are reproducible.

Goal(s): To measure longitudinal reproducibility of 13C MRS liver glycogen concentration in children 8-12yrs.

Approach: For 24 participants intra- and inter- reproducibility measures were calculated by two raters and automated analysis across two visits with two timepoints.

Results: Intra- and inter-subject measures for liver glycogen concentration in children were similar to those previously reported in adults, with coefficient of variation ranging from 22-38%.

Impact: With both intra-subject and inter-subject reproducibility of liver glycogen concentration in children matching literature values for adults, this shows the viability of MRS as a tool to measure liver glycogen in a diverse population.

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