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Abstract #0544

High-Resolution Structural and Functional Lung Assessment of Neonates with Bronchopulmonary Dysplasia using 3D UTE FLORET MRI

Samal Munidasa1, Nara S Higano1, Matthew Willmering1,2, Alexander Matheson1, Paul S Kingma3, Erik B Hysinger1,2,4, and Jason C Woods1,2,4
1Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 4Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States

Synopsis

Keywords: Neonatal, Lung, PREFUL, bronchopulmonary dysplasia, neonatal, FLORET UTE

Motivation: Existing 2D multi-slice MRI-based regional ventilation evaluation of neonatal lung diseases has limited through-plane resolution and may miss heterogeneous functional lung abnormalities across the entire lung.

Goal(s): To demonstrate the feasibility of 3D ultra echo time (UTE) free-breathing lung MRI for structural and functional assessment of infants with bronchopulmonary dysplasia (BPD).

Approach: Infants with moderate to severe BPD underwent free-breathing UTE MRI, and regional ventilation was assessed using the phase-resolved functional lung (PREFUL) method.

Results: 3D UTE PREFUL MRI was feasible and captured both regional ventilation function and quantitative structural abnormalities of the entire lung in infants with BPD.

Impact: Existing 2D multi-slice MRI-based regional ventilation has limited in spatial resolution. Whole-lung ventilation assessment is feasible using 3D ultra-short echo time sequences and can be directly compared to structural abnormalities, with demonstrated potential for clinical translation, even in young infants.

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Keywords