Abstract #0545
Feasibility of Multi-Site Structural and Functional Pulmonary MRI in Non-Sedated Infants Born Extremely Preterm
Brandon Zanette1, Filip Klimeš2,3, Andreas Voskrebenzev2,3, Ailish Coblentz4,5, Roya Shamsi6, Jens Vogel-Claussen2,3, Mary-Louise C Greer4,5, Nishard Abdeen7, Sylvain Deschenes8, Zonah Khumalo9, Theo J Moraes1,10, Adel Mohamed11, Gabriel Altit12, Thuy Mai Luu13, Larry C Lands14, Giles Santyr1,15, and Sherri L Katz16,17
1Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada, 2Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 3Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 4Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, ON, Canada, 5Department of Medical Imaging, University of Toronto, Toronto, ON, Canada, 6Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada, 7Department of Medical Imaging, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, 8Department of Radiology, CHU Ste-Justine, Université de Montréal, Montreal, QC, Canada, 9Department of Medical Imaging, Montreal Children's Hospital, McGill University Health Centre Research Institute, Montreal, QC, Canada, 10Division of Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada, 11Division of Neonatology, Department of Pediatrics, University of Toronto, Toronto, ON, Canada, 12Division of Neonatology, NeoCardio Lab, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre Research Institute, Montreal, QC, Canada, 13Department of Pediatrics and Research Centre, CHU Ste-Justine, Université de Montréal, Montreal, QC, Canada, 14Division of Pediatric Respiratory Medicine, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Centre Research Institute, Montreal, QC, Canada, 15Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 16Division of Respirology, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, 17Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
Synopsis
Keywords: Lung, Lung, UTE, PREFUL, Ventilation, Perfusion, Bronchopulmonary Dysplasia, Premature, Infant
Motivation: Ultrashort echo time (UTE) and Phase-resolved functional lung (PREFUL) MRI hold promise for pulmonary structure, ventilation, and perfusion evaluation in preterm infants but have not been evaluated across multiple sites.
Goal(s): To demonstrate UTE/PREFUL MRI feasibility across multiple sites in extremely preterm infants, without need for exogenous contrast agents or sedation.
Approach: Across four sites, infants born <29 weeks gestation were scanned with UTE and PREFUL MRI at corrected gestational ages of 36-44 weeks. UTE score, ventilation and perfusion defect percent (VDP and QDP) were evaluated.
Results: 25 participants were recruited and scanned. Elevated UTE scores, VDP, and QDP were observed.
Impact: Across multiple sites, UTE and PREFUL MRI is feasible in non-sedated infants born <29 weeks and sensitive to structural, ventilation, and perfusion abnormalities in this population.
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