Abstract #0546

Regional evaluation of pulmonary blood arrival time assessed by matrix pencil decomposition MRI in pediatric patients with cystic fibrosis

Alexandra De Silvestro^1,2, Grzegorz Bauman^3,4, Orso Pusterla^3,4, Jakob Usemann^2,5,6, Gabriele Raffler^2,5, Simon Vogt^2,5, Julia Geiger^2,7, Oliver Bieri^3,4, Alexander Moeller^2,5, Christian Kellenberger^2,7, and Rahel Heule^1,2

¹Center for MR-Research, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland, ²Children’s Research Center, University Children’s Hospital Zurich, University of Zurich, Zurich, Switzerland, ³Department of Radiology, Division of Radiological Physics, University Hospital Basel, Basel, Switzerland, ⁴Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland, ⁵Department of Respiratory Medicine, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁶University Children's Hospital Basel (UKBB), Basel, Switzerland, ⁷Department of Diagnostic Imaging, University Children’s Hospital Zurich, University of Zurich, Zurich, Switzerland

Synopsis

Keywords: Lung, Perfusion

Motivation: Regional pulmonary blood arrival time (rpBAT) is a novel parameter derived from non-invasive matrix pencil decomposition MRI, reflecting the transit time of the arterial pulse wave.

Goal(s): We aimed to evaluate its clinical potential.

Approach: rpBAT was assessed in 20 pediatric patients with cystic fibrosis, in regions with and without perfusion defect as defined by the regional perfusion amplitude.

Results: A rpBAT delay in regions with perfusion defect was found. The delay correlated strongly with total MR-lung volumes. Consequently, we assume an influence of vessel distances on rpBAT delay, but found indications for further impact factors including structural and functional lung alterations.

Impact: The delay of regional pulmonary blood arrival time in perfusion defects of CF patients correlates with total MR-lung volume, and is presumably impacted by impaired lung structure and function. Further investigation may lead to more sensitive evaluation of lung pathologies.

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