Meeting Banner
Abstract #0551

Accuracy of OPTIMIST trial criteria on MRI to predict pathologic complete response following neoadjuvant systemic therapy

HEERA YOEN1, Na Hye Han1, Nariya Cho1, Ji-Jung Jung2, Jayme Natasha Paggao3, Hong-Kyu Kim2, and Han-Byoel Lee2
1Radiology, Seoul National University Hospital, Seoul, Korea, Republic of, 2Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, 3Surgery, University of the East Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines

Synopsis

Keywords: Breast, Treatment Response

Motivation: The omission of surgery is gaining attention for breast cancer patients who achieve a pathologic complete response (pCR) following neoadjuvant systemic therapy (NST), emphasizing the need for accurate pre-surgical prediction of NST response.

Goal(s): To evaluate whether post-NST radiologic criteria from the OPTIMIST trial reliably predict pCR status.

Approach: We retrospectively assessed radiologic criteria (MRI lesion-to-background signal-to-enhancement ratio [SER]≤ 1.6, size≤ 1.0 cm, calcification≤ 2.0 cm) in breast cancer patients treated with NST followed by surgery to determine their association with pCR.

Results: The enrollment criteria, especially SER, accurately predicted pCR and is applicable in the clinical setting.

Impact: Incorporating the MRI size, SER, and calcification size for accurate pCR prediction supports designing de-escalation trials in good NST responders.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords