Keywords: Cartilage, Joints, UTE-T2*, ACL, knee
Motivation: Clinical evidence of symptomatic benefit concurrent with deep knee cartilage compositional improvement following ACL reconstruction (ACLR) is lacking.
Goal(s): To evaluate relationships between deep cartilage UTE-T2* changes and concurrent symptomatic changes following ACLR.
Approach: UTE-T2* maps and patient reported outcomes were acquired at 7-weeks and again 2-years after ACLR in 48 patients. Smallest detectable UTE-T2* difference was calculated from test-retest UTE-T2* maps in 10 uninjured controls.
Results: On average, UTE-T2* in deep femoral cartilage increased over 2 years following ACLR, and patients reported substantial symptomatic improvements over this time. Greater reductions in patellar cartilage UTE-T2* associated with greater improvements in patients’ knee pain.
Impact: UTE-T2* qMRI evaluation shows that longitudinal changes to deep knee cartilage composition associate with concurrent clinically meaningful improvements in patient reported knee pain following ACL reconstruction.
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