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Abstract #0562

Assessment of lower limb lesions in diabetic patients utilizing BOLD-MRI at 7T: a feasibility study

Huilin Pang1, Xinyu Zhang1, Jiafei Chen1, Zhiming Zhen1, Suyi Zhou1, Wei Chen2, and Wei Chen1
17T Magnetic Resonance Translational Medicine Research Center, Department of Radiology, Southwest Hospital, Army Medical University, Chongqing, China, 2MR Research Collaboration Team, Siemens Healthineers Ltd., Wuhan, China

Synopsis

Keywords: Muscle, fMRI Analysis, 7T MRI

Motivation: BOLD-MRI offers a sensitive and non-invasive way for the quantitative assessment of lower limb perfusion and oxygenation status, facilitating early evaluation of lower limb lesions in diabetic patients.

Goal(s): To evaluate the potential of BOLD-MRI in assessing the severity of lower limb lesions in diabetic patients.

Approach: Ischemia-reperfusion model in diabetic patients by transient compression on mid-thigh was established. 7T BOLD-MRI examination was performed and perfusion parameters were extracted and analyzed.

Results: Time-to-Peak (TTP) parameter demonstrated high diagnostic accuracy for the early diagnosis and classification of diabetic lower limb lesions, showing a significant correlation with the clinical indicator ankle brachial index (ABI).

Impact: BOLD-MRI could enhance the precision in assessing lower limb perfusion in diabetes, thereby aiding accurate classification and diagnosis at early stages while overcoming current diagnostic limitations through non-invasive quantitative analysis of peripheral lesions associated with diabetes.

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