Abstract #0568
Clinical validation of a multi-modal ultra-fast MRI protocol for dementia diagnosis
Haroon R Chughtai1,2, David L Thomas3,4, Miguel Rosa-Grilo3, Carole H Sudre5,6,7, Bhavana S Solanky1,8, Emma Lim9,10, Dermot Mallon10, H Rolf Jäger4,10, Lloyd Prosser3, Ian B Malone3, Daniel C Alexander6, Frederik Barkhof3,4,6,11, Nick C Fox3, Catherine J Mummery3, and Geoff J M Parker1,8,12
1UCL Hawkes Institute, Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2Centre for Advanced Research Computing (ARC), University College London, London, United Kingdom, 3Dementia Research Centre (DRC), UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 4Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 5MRC Unit for Lifelong Health and Ageing at UCL, Department of Population Science and Experimental medicine, University College London, London, United Kingdom, 6UCL Hawkes Institute, Department of Computer Science, University College London, London, United Kingdom, 7School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 8NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 9Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, 10Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 11Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 12Bioxydyn Limited, Manchester, United Kingdom
Synopsis
Keywords: Dementia, Alzheimer's Disease
Motivation: Despite the key role of MRI in dementia diagnosis and monitoring, long scan times limit accessibility and increase costs resulting in a disparity in care.
Goal(s): To validate our sub-7-minute comprehensive MRI protocol incorporating Wave-CAIPI acceleration against a standard clinical 17-minute protocol, through multi-modal assessment.
Approach: Validation through: (1) blinded neuroradiologist assessment, (2) automated brain morphometry comparison, and (3) white matter hyperintensity quantification.
Results: Relative to the clinical standard, our ultra-fast protocol demonstrated non-inferiority with intra-rater kappa >0.80, volumetric differences <4%, and maintained WMH detection sensitivity, while reducing scan time from 17:39 min to 6:29 min.
Impact: By significantly decreasing scan time, our validated ultra-fast protocol enables wider access to MRI for patients with dementia, whilst maintaining diagnostic utility, reducing healthcare costs and improving the patient experience.
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