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Abstract #0569

Mapping the Progressive Degeneration of the Olfactory Cortex from Normal Cognition to Alzheimer's Disease

CHUNJIE GUO1, SIMIN YANG1, YUE CAO1, BO XIE2, ZHIWEI SHEN3, NING ZHENG3, YU YANG2, and HUIMAO ZHANG1
1Radiology, The First Hospital of Jilin University, Changchun, China, 2Neurology, The First Hospital of Jilin University, Changchun, China, 3Philips healthcare, Beijing, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, mild cognitive impairment (MCI), olfaction, primary olfactory cotex (POC), fMRI (task based), fMRI (resting state)

Motivation: Olfactory dysfunction is an early indicator of Alzheimer's disease (AD), with olfactory cortical changes as potential progression biomarkers.

Goal(s): To map olfactory cortex degeneration patterns across normal cognition (NC), mild cognitive impairment (MCI), and AD.

Approach: Using structural MRI, resting-state fMRI, and olfactory-task fMRI to assess olfactory regions in 105 participants, alongside olfactory and cognitive assessments.

Results: Findings suggested a progression from unilateral degeneration in dominant olfactory cortex (NC-MCI) to widespread bilateral impairment (MCI-AD).

Impact: These findings advance our understanding of hemispheric vulnerability in early neurodegeneration, offering potential insights for therapeutic intervention before widespread impairment occurs. The identified progression pattern may contribute to developing more sensitive early detection strategies in AD.

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