Abstract #0570

Impaired mitochondrial energy metabolism related to astrocyte in the brain of Alzheimer’s disease

Maiko Ono¹, Kosei Hirata^2,3, Rena Kono¹, Keita Saito¹, Yuki Maeda⁴, Yurika Abe⁵, Masashi Kawami⁴, Hiroshi Shimizu⁶, Yasuo Uchida^4,5, and Yuhei Takado¹

¹National Institutes for Quantum Science and Technology, Chiba, Japan, ²Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Institute of Science Tokyo, Tokyo, Japan, ⁴Hiroshima University, Hiroshima, Japan, ⁵Tohoku University, Sendai, Japan, ⁶Niigata University, Niigata, Japan

Synopsis

Keywords: Alzheimer's Disease, Metabolism

Motivation: The pathogenesis of Alzheimer's disease (AD) remains unclear. Recently, abnormalities in brain energy metabolism associated with AD have attracted attention.

Goal(s): This study aimed to gain insight into the background mechanisms of abnormal brain energy metabolism associated with AD pathology.

Approach: We performed proteomic analysis in brain tissues derived from AD patients and AD model mice, and in vivo metabolic assessment with ¹H MRS and hyperpolarized [1-¹³C]pyruvate MRS in AD model mice.

Results: Impaired mitochondrial energy metabolism related to astrocyte was implied in the brain of AD patients and AD mouse model.

Impact: This study provides insights into impaired mitochondrial energy metabolism associated with AD. Hyperpolarized [1-¹³C]pyruvate MRS detected hippocampal metabolic changes in AD mouse model at early pathological stages, and is expected to be applied to pathological studies of AD.

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