Abstract #0582

Disrupted Excitatory-Inhibitory Balance in the Motor Cortex of Parkinson’s Disease: A 7T MRS Study at Rest and Motor Tasks

Ning Wei¹, Dongning Su², Zhe Zhang¹, Young Woo Park³, Dinesh Deelchand³, Guglielmo Genovese^3,4, Malgorzata Marjanska³, Tao Feng², Jing Jing¹, and Zihao Zhang^5,6,7

¹Tiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ²Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ³Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, American Samoa, ⁴Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway, ⁵State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ⁶Anhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing, Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China, ⁷University of Chinese Academy of Sciences, Beijing, China

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, Magnetic Resonance Spectroscopy；Ultra-high Field；Excitatory-inhibitory Balance

Motivation: Understanding the role of neurotransmitter imbalance in cortical areas like the motor cortex is crucial for addressing motor dysfunction in Parkinson’s Disease (PD).

Goal(s): Assess changes in GABA and glutamate levels in the motor cortex of PD patients.

Approach: This study used 7T MRS to evaluate excitatory-inhibitory (E/I) balance in the motor cortex of PD patients compared to healthy controls. GABA and glutamate concentrations were measured under baseline and motor task conditions.

Results: PD patients showed increased GABA levels and reduced E/I ratio, indicating heightened inhibition and impaired motor regulation.

Impact: This study highlights disrupted inhibitory-excitatory balance in PD, providing insights for targeted therapies to improve motor function. It also prompts further investigation into neurotransmitter regulation, potentially benefiting clinicians and researchers in PD treatment development.

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