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Abstract #0592

Assessing the reproducibility of downfield MRSI in the human brain at 3T

İpek Özdemir1, Semra Etyemez2, and Peter B Barker1,3
1Johns Hopkins University, Baltimore, MD, United States, 2Weill Cornell Medicine, New York City, NY, United States, 3Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Spectroscopy, Brain, Reproducibility, Test-Retest, Downfield MRSI

Motivation: Downfield proton MR Spectroscopic Imaging (DF-MRSI) is a recently developed technique for mapping exchangeable protons which resonate downfield from water in the proton spectrum. To date, the reproducibility of this technique has not been evaluated.

Goal(s): To quantitatively evaluate the reproducibility of the major peaks in the downfield spectrum using 3D DF-MRSI at 3T.

Approach: 3D DF-MRSI data were collected from five healthy volunteers at two visits

Results: Mean coefficients of variance (CV) were 17% or lower for amide and DF7.9 resonances.

Impact: 3D DF-MRSI at 3T is a highly reproducible tool. In the future it may be useful in for studies of amides and other resonances in pathological conditions.

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