Keywords: Spectroscopy, Brain, Reproducibility, Test-Retest, Downfield MRSI
Motivation: Downfield proton MR Spectroscopic Imaging (DF-MRSI) is a recently developed technique for mapping exchangeable protons which resonate downfield from water in the proton spectrum. To date, the reproducibility of this technique has not been evaluated.
Goal(s): To quantitatively evaluate the reproducibility of the major peaks in the downfield spectrum using 3D DF-MRSI at 3T.
Approach: 3D DF-MRSI data were collected from five healthy volunteers at two visits
Results: Mean coefficients of variance (CV) were 17% or lower for amide and DF7.9 resonances.
Impact: 3D DF-MRSI at 3T is a highly reproducible tool. In the future it may be useful in for studies of amides and other resonances in pathological conditions.
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