Keywords: Spectroscopy, Metabolism, protein binding, microenvironment, metabolite diffusivity, field dependence
Motivation: The methylene MRS signal of cerebral ethanol was reported invisible by some and fully-detectable by others.
Goal(s): Elucidate reasons for the limited visibility of a submoiety of a cerebral molecule
Approach: Record various single-voxel and MRSI data before/after ethanol ingestion to investigate MT-effects (with/without water-presaturation), resonance-frequency-dependence (spectra from 1.5T, 3T, 7T), T2-relaxation (multiple TEs), molecular diffusion properties (diffusion-weighted MRS using short diffusion-times and double-diffusion-encoding), and compartmental effects (MRSI and WM/GM/CSF-differentiation)
Results: Detectability of CH2-signals of brain ethanol varies with moiety-specific, B0-dependent T2-relaxation and appears brain-compartment specific. Magnetization-exchange doesn’t play a role and diffusion properties don’t evidence stable binding to large molecules/structures
Impact: The explored partial and B0-dependent detectability of brain ethanol may give insight into its microenvironment and could scale with the extent of physiologic effects. Ethanol’s differential and field-dependent T2s may serve as prototype for studying binding properties of endogenous metabolites.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords