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Abstract #0597

Clues from 1H MR spectroscopy about the cerebral micro-environment of ingested ethanol

Roland Kreis1,2, Jessie Mosso3,4,5, Guodong Weng6, Kadir Simsek7, Chris Boesch8, Johannes Slotboom6, and André Döring3
1MR Methodology Group, Institute of Diagnostic and Interventional Neuroradiology, University Bern, Bern, Switzerland, 2Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, 3CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 4Animal Imaging and Technology, EPFL, Lausanne, Switzerland, 5Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 6Inselspital Bern, Bern, Switzerland, 7CUBRIC Cardiff, Cardiff, United Kingdom, 8University Bern, Bern, Switzerland

Synopsis

Keywords: Spectroscopy, Metabolism, protein binding, microenvironment, metabolite diffusivity, field dependence

Motivation: The methylene MRS signal of cerebral ethanol was reported invisible by some and fully-detectable by others.

Goal(s): Elucidate reasons for the limited visibility of a submoiety of a cerebral molecule

Approach: Record various single-voxel and MRSI data before/after ethanol ingestion to investigate MT-effects (with/without water-presaturation), resonance-frequency-dependence (spectra from 1.5T, 3T, 7T), T2-relaxation (multiple TEs), molecular diffusion properties (diffusion-weighted MRS using short diffusion-times and double-diffusion-encoding), and compartmental effects (MRSI and WM/GM/CSF-differentiation)

Results: Detectability of CH2-signals of brain ethanol varies with moiety-specific, B0-dependent T2-relaxation and appears brain-compartment specific. Magnetization-exchange doesn’t play a role and diffusion properties don’t evidence stable binding to large molecules/structures

Impact: The explored partial and B0-dependent detectability of brain ethanol may give insight into its microenvironment and could scale with the extent of physiologic effects. Ethanol’s differential and field-dependent T2s may serve as prototype for studying binding properties of endogenous metabolites.

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Keywords