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Abstract #0600

Quantification of NAD+ proton cross-relaxation with water using downfield 1H MRS in the human brain at 7 T

Sophia Swago1, Neil E. Wilson2, Mark A. Elliott2, Ryan R. Armbruster1, Ravi Prakash Reddy Nanga2, Ravinder Reddy2, and Walter R. Witschey2
1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Spectroscopy, Brain

Motivation: NAD+ plays a pivotal role in metabolism and its cross-relaxation with water has the potential to be a biomarker of health and disease.

Goal(s): Our goal was to determine the rate of NAD+ cross-relaxation in the human brain in vivo at 7T.

Approach: We utilized spectrally-selective downfield spectroscopy in paired saturation recovery experiments and fit two models of longitudinal recovery.

Results: We measured an average 7.6-fold increase in apparent T1 relaxation when utilizing a broadband saturation pulse compared to a selective saturation pulse and a cross-relaxation rate of 3.9±1.5 Hz for the H2 and H6 protons of NAD+.

Impact: NAD+ cross-relaxation in human brain can be exploited to increase sensitivity through T1-shortening, and its quantification may provide insights into metabolite binding in vivo.

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Keywords