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Abstract #0601

Measuring Lactate Levels in Gray and White Matter of the healthy Human Brain using semi-LASER MRSI with Concentric Ring Trajectory Encoding at 3T

Viola Bader1, Bernhard Strasser1, Wolfgang Bogner1,2, Lukas Hingerl1, Sabina Frese1, Anna Duguid1, Aaron Osburg1, Małgorzata Marjańska3, Stanislav Motyka1,2, Martin Krššák4, Thomas Scherer4, Rupert Lanzenberger5, and Fabian Niess1
1High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 2Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK), Vienna, Austria, 3Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 4Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria, 5Department of Psychiatry and Psychotherapy, Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria

Synopsis

Keywords: Spectroscopy, Spectroscopy, Brain, MRSI, Concentric Ring Trajectory , Lactate, Metabolism

Motivation: Lactate is an important metabolite in the healthy human brain and serves as a marker for various pathologies. A non-invasive detection of lactate levels could enhance our understanding of brain metabolism, but low baseline concentrations and overlapping lipid and macromolecule resonances complicate reliable lactate quantification and limit detection to single-voxel approaches with decreased specificity.

Goal(s): Quantify regional Lac levels in healthy human brain using MRSI selectively in GM/WM dominated regions.

Approach: 1H-semi-LASER localization module was combined with 3D-concentric-ring-trajectory readout.

Results: Similar Lac levels were observed in GM/WM dominated regions (cLacGM/WM=1.28±0.37/1.34±0.19mM), with a negative correlation with time in GM regions for repeated scans.

Impact: Capturing time-resolved regional Lac-levels could improve understanding of various pathologies characterized by abnormal levels. The proposed versatile sLASER-CRT-MRSI-sequence allows spectral averaging over specific brain regions and could help detect metabolic changes associated with pathologies and improve diagnostic and therapeutic approaches.

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Keywords