Abstract #0674

Longitudinal evaluation of MRgFUS lesion characteristics and retrospective identification of the final target location using dMRI

Amritha Nayak¹, Linika Goel², Angela Bissoli³, Giuseppe Kenneth Ricciardi⁴, Elisa Ciceri⁵, Maximal Fonda¹, and Carlo Pierpaoli¹

¹Laboratory on Quantitative Medical Imaging, NIBIB, National Institutes of Health (NIH), Bethesda, MD, United States, ²Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ³Department of Neuroradiology, UOC Neuroradiologia S. Bortolo, Vicenza, Italy, ⁴Neuroradiology, AOUVR Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy, ⁵Imaging Radiology and Interventional Neuroradiology, , IRCCS Fondazione Istituto Neurologico "C.Besta", Milan, Italy

Synopsis

Keywords: MR-Guided Focused Ultrasound, Diffusion Analysis and Visualization, MR-guided interventions

Motivation: Diffusion MRI (dMRI) can offer structural specificity with sensitivity in capturing quantitatively the changes in tissue due to damage or recovery.

Goal(s): Use dMRI in a MRgFUS study to assess the lesion characteristics and pinpoint the location with highest tissue damage at the core of the lesion to transfer it to the presurgical dMRI scan.

Approach: Measurements are performed, per timepoint, on the lesion identified with a three ring appearance from the ~27hour MD scan.

Results: The dMRI metrics differentiated regions with edema and highest tissue damage in the lesion. Additionally, the core of the lesion was identified on the presurgical dMRI scan.

Impact: The dMRI quantitative measurements in the MRgFUS lesion are able to differentiate between regions of highest tissue damage and edema. Clinicians can use these measurements to assess the location of final target placement and correlate with clinical outcome measures.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.