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Abstract #0681

Feasibility of MR-guided RF Ablation and Lesion Evaluation in an Isolated Beating Pig Heart Platform

Eric Schrauben1, Luuk Hopman2, Jules Nelissen1, Pieter J Reitzema2, Bart Smeets3, Renate Boekhoven3, Daniel Sunnarborg4, Jouke Smink5, Johannes Niessen6, Cornelis Allaart2, Marco Götte2, and Aart Nederveen1
1Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 2Cardiology, Amsterdam UMC, Amsterdam, Netherlands, 3LifeTec Group B.V., Eindhoven, Netherlands, 4Imricor Medical Systems, Burnsville, MN, United States, 5Philips Healthcare, Best, Netherlands, 6Pathology, Amsterdam UMC, Amsterdam, Netherlands

Synopsis

Keywords: MR-Guided Interventions, Interventional Devices

Motivation: Validation of interventional cardiovascular MR procedures such as radiofrequency ablation within controlled environments and correlation of findings with histopathological outcomes remains elusive.

Goal(s): To evaluate the feasibility of MR-guided radiofrequency ablation in an isolated pig heart platform and to assess post-ablation lesions.

Approach: Combining a previously reported isolated pig heart platform, interventional cardiac catheters tuned to 3T tracked in real-time, and RF ablation and assessment in a clinical MR environment.

Results: Imaging and catheter navigation were combined to provide detailed visualization and characterization of ablation lesions, including reduced cardiac function (EFpre=24% vs EFpost=8%) and lesion core native T1 (T1pre=1286±41 ms vs T1post=1059±160 ms).

Impact: The collaborative combination proposed here lays the groundwork for future innovations in MR-guided cardiac interventions by offering real-time imaging, lesion characterization, and a controlled platform for testing new techniques.

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