Abstract #0689

Regional Outlier Analysis of Longitudinal MAP-MRI Changes following Mild Traumatic Brain Injury

Mihika Gangolli^1,2,3,4, Priyanka Nadar^1,5, Luca Marinelli⁶, Peter J. Basser^1,2, and Alexandru Avram^1,2

¹Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States, ²Military Traumatic Brain Injury Initiative (MTBI2), Bethesda, MD, United States, ³Uniformed Services University of the Health Sciences, Bethesda, MD, United States, ⁴The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, United States, ⁵Division of Internal Medicine, The University of Colorado Anschutz Medical Campus, Aurora, CO, United States, ⁶GE HealthCare Technology & Innovation Center, Niskayuna, NY, United States

Synopsis

Keywords: Traumatic Brain Injury, biomarkers, longitudinal imaging

Motivation: Cross sectional radiological assessments of mild traumatic brain injury (mTBI) often produce conflicting findings with poor correlation to clinical outcomes.

Goal(s): Mean apparent propagator MRI (MAP-MRI) in a pilot longitudinal study is proposed to probe complex alterations in tissue microstructure following mTBI.

Approach: Quantitative region of interest analysis of MAP-MRI and DTI-derived metrics was performed in a pilot cohort of mTBI patients at four timepoints up to 90 days following injury.

Results: Several MAP-MRI derived parameters had increased intersession variability in white matter tracts and deep gray matter nuclei relative to healthy controls during the 90-day period of observation.

Impact: Longitudinal monitoring of changes in MAP-MRI metrics may provide a more comprehensive means to study pathological alterations that evolve at multiple timepoints in mTBI, where current image-based biomarkers lack the sensitivity and specificity to predict outcome.

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