Keywords: Traumatic Brain Injury, Analysis/Processing, brain entropy, traumatic brain injury, NIH toolbox, Cognitive Tests
Motivation: Mild traumatic brain injury (mTBI) often leads to long-term physical, cognitive, and emotional challenges. Resting-state fMRI studies have shown functional brain changes in mTBI, but a comprehensive understanding of brain alterations remains limited.
Goal(s): This study aims to examine brain entropy (BEN) in mTBI patients over time, exploring its potential association with neurocognition and recovery.
Approach: Using longitudinal rs-fMRI data, we assessed BEN—a novel metric linked to brain function and pathology—in mTBI patients, analyzing changes from the acute to chronic phases.
Results: Our preliminary results suggest increased BEN during the acute phase of mTBI, with normalization as cognitive function improves over time.
Impact: This study positions brain entropy (BEN) as a potential biomarker for tracking recovery in mTBI. BEN’s sensitivity to acute functional changes and its normalization with cognitive improvement could enhance diagnostic precision and inform therapeutic interventions in mTBI management.
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