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Abstract #0690

Differences in Brain Entropy and Cognitive Function Between Mild TBI Patients and Healthy Controls: A Longitudinal Perspective

Li Jiang1,2, Ze Wang1,2, Andrew Furman1,2, Xiao Liang1,2, Steven Roys1,2, Rosy Linda Njonkou Tchoquessi1,2, Prashant Raghavan Raghavan1, Rao Gullapalli1,2, and Jiachen Zhuo1,2
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland Baltimore, Baltimore, MD, United States, 2Center for Advanced Imaging Research, University of Maryland Baltimore, Baltimore, MD, United States

Synopsis

Keywords: Traumatic Brain Injury, Analysis/Processing, brain entropy, traumatic brain injury, NIH toolbox, Cognitive Tests

Motivation: Mild traumatic brain injury (mTBI) often leads to long-term physical, cognitive, and emotional challenges. Resting-state fMRI studies have shown functional brain changes in mTBI, but a comprehensive understanding of brain alterations remains limited.

Goal(s): This study aims to examine brain entropy (BEN) in mTBI patients over time, exploring its potential association with neurocognition and recovery.

Approach: Using longitudinal rs-fMRI data, we assessed BEN—a novel metric linked to brain function and pathology—in mTBI patients, analyzing changes from the acute to chronic phases.

Results: Our preliminary results suggest increased BEN during the acute phase of mTBI, with normalization as cognitive function improves over time.

Impact: This study positions brain entropy (BEN) as a potential biomarker for tracking recovery in mTBI. BEN’s sensitivity to acute functional changes and its normalization with cognitive improvement could enhance diagnostic precision and inform therapeutic interventions in mTBI management.

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Keywords