Meeting Banner
Abstract #0706

Evidence of Incoherent Fluids Flow in the Human Brain from Multidimensional Intravoxel Incoherent Motion MRI

Chenyang Li1,2, Yulin Ge1,2, and Jiangyang Zhang1,2
1Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, 2Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: IVIM, Diffusion Acquisition, Multidimensional MRI; IVIM; CSF flow

Motivation: The human brain contains multiple fluid compartments, including blood, cerebrospinal fluid (CSF), and tissue water. While microvascular perfusion is well-studied using intravoxel incoherent motion (IVIM), evidence on flow in other fluid compartments remains limited.

Goal(s): To develop in vivo multi-dimensional MRI methods to investigate potential contributions of CSF movements in the IVIM regime.

Approach: We implemented MADCO-accelerated joint T1-Diffusion and T2-Diffusion measurements to resolve subvoxel heterogeneities of IVIM components in living human brains.

Results: Analysis of T1-Diffusion and T2-Diffusion correlation spectra revealed distinct signatures of CSF flow in addition to microvascular perfusion, particularly in the subarachnoid space.

Impact: This multidimensional MRI approach reveals multiple pseudo diffusion components in the living human brain beyond traditional IVIM measurements, providing a novel framework to characterize distinct fluid dynamics and potentially advance our understanding of brain fluid transport systems.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords