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Abstract #0715

Studying the effects of relaxation on estimates of white-matter microstructure with diffusion encoded measurements

Alfredo Ordinola1, Magnus Herberthson2, and Evren Özarslan1,3
1Department of Biomedical Engineering, Linköping University, Linköping, Sweden, 2Department of Mathematics, Linköping University, Linköping, Sweden, 3Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden

Synopsis

Keywords: Diffusion Modeling, Diffusion Modeling, Relaxation

Motivation: Biophysical models developed for diffusion magnetic resonance often disregard relaxation effects when estimating microstructure parameters.

Goal(s): Show the impact of relaxation effects on the estimated parameters obtained from white-matter spinal cord data.

Approach: A model for general gradient waveforms was implemented and employed for estimating parameters of white-matter compartments from mouse spinal cord data. The fits were performed for versions of the model with and without transverse relaxation effects.

Results: The estimated parameters of white-matter microstructure show a strong dependence on the relaxation parameters.

Impact: The implemented framework shows that relaxation effects greatly impact estimated micro-structure parameters in tissue, even if they are normalized by non diffusion-weighted data. Moreover, the implemented model can be employed to assess biases in previously presented frameworks

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Keywords