Abstract #0718

Estimation of Cerebral Oxygen Extraction Fraction (OEF) by Haematocrit-Corrected QQ (QSM + qBOLD) in Sickle Cell Anaemia

Isabelle Hawley¹, Mitchel Lee², Hanne Stotesbury¹, Karin Shmueli², Chris Clark¹, Junghun Cho³, and Fenella Kirkham¹

¹Developmental Neurosciences, UCL Great Ormond St. Institute of Child Health, London, United Kingdom, ²Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ³Department of Biomedical Engineering, University at Buffalo, The State University of New York, New York, NY, United States

Synopsis

Keywords: Oxygenation, Genetic Diseases, Oxygenation, Oxygen Extraction Fraction, QQ, QSM + qBOLD, Sickle cell disease, Sickle cell anaemia, OEF, SCD, SCA, brain, biomarker, haemltocrit

Motivation: Cerebral injury in Sickle cell anaemia (SCA) is hypothesised to be caused by an inability to maintain stable oxygen delivery to tissue. A biomarker of tissue vulnerability is the cerebral metabolic rate of oxygen consumption (CMRO₂).

Goal(s): Estimate regional Oxygen Extraction fraction (OEF) and CMRO₂in participants with SCA and healthy controls using non-invasive regional MRI.

Approach: QQ (QSM + qBOLD) was used to estimate voxel-wise OEF – enabling calculation of regional CMRO₂.

Results: SCA participants had significantly higher cerebral blood flow and OEF compared to controls. CMRO₂ was higher in white matter in children, but not adults, with SCA.

Impact: QQ (QSM + qBOLD) enables a non-invasive method of studying haemodynamic health via regional estimation of OEF and CMRO₂ in participants, of all ages, with SCA. The differences found suggest the important role of cerebral metabolism in tissue injury.

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