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Abstract #0721

Accelerated 3D mapping of whole brain venous oxygenation with nested-shift under sampling and ESPIRIT reconstruction

Yiwen Hong1, Dengrong jiang2, Yi Zhang1, Yi-Cheng Hsu3, Hanzhang Lu4, Dan Wu1, and Zixuan Lin1
1Department of Biomedical Engineering, Zhejiang University, HangZhou, China, 2School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 3MR Collaboration, Siemens Healthineers Ltd, Shanghai, China, 4Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Oxygenation, Oxygenation

Motivation: Non-invasive measurement of cerebral venous oxygenation (Yv) is essential, but existing method is limited to 2D due to technical difficulties, especially long scan duration.

Goal(s): Developing a 3D T2-Relaxation-Under-Velocity-Encoding-and-Rapid-Acquisition (3D TRU-VERA) sequence for whole brain Yv quantification, including cortical and deep veins, while minimizing scan time.

Approach: Optimized under-sampling schemes and reconstruction methods for accurate Yv quantification, validated with 2D techniques and tested for reproducibility and sensitivity to oxygenation change.

Results: Nested-shift under-sampling with ESPIRIT provided optimal accuracy, achieved 1.04×1.04×2mm³ resolution in 7min23sec. 3D TRU-VERA demonstrated reliable Yv measurements, comparable to TRUST and TRUPC, and showing Yv reduction across veins post-caffeine.

Impact: The 3D TRU-VERA sequence enables rapid, non-invasive assessment of venous oxygenation (Yv) across the entire brain, providing vessel-specific quantification and comprehensive evaluation of regional cerebral oxygen metabolism.

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Keywords