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Abstract #0722

A Gradient Echo-Spin Echo BOLD framework for quantitative mapping of OEF and CMRO2 with calibrated functional MRI

Antonio Maria Chiarelli1, Sara Pomante1, Fabrizio Fasano2, Maria Eugenia Caligiuri3, Stefano Censi1, Davide Di Censo1, Ekaterina Bliakharskaia1, Manuela Carriero1, Francesca Graziano1, Alessandra Stella Caporale1, Emma Biondetti1, Richard Wise1, and Michael Germuska4
1Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio of Chieti-Pescara, Chieti, Italy, 2Siemens Healthineers, Forchheim, Germany, 3Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy, 4Department of Radiology, University of California Davis, Sacramento, CA, United States

Synopsis

Keywords: Oxygenation, Oxygenation, Brain Oxygen Consumption, calibrated fMRI, Spin-Echo BOLD fMRI

Motivation: Calibrated (c-)fMRI produces OEF and CMRO2 maps using BOLD-ASL recordings during isometabolic modulations of brain physiology. However, the method is limited by the low SNR of ASL.

Goal(s): To develop and validate an easily implementable, high SNR, Gradient Echo-Spin Echo (GE/SE) BOLD c-fMRI approach for OEF estimation through a single vasodilatory stimulation, potentially not requiring ASL.

Approach: We performed Monte Carlo simulations and GE/SE acquisitions during breath-holding to assess the method's feasibility.

Results: GM OEF and CMRO2 maps were derived using the new framework, both with and without ASL information. Both measures correlated with macrovascular measures of OEF.

Impact: The GE/SE BOLD calibrated fMRI framework appears feasible. It may allow for robust inference of OEF and CMRO2 maps through a single vasodilatory stimulus and without the need for functional ASL recordings.

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Keywords