Keywords: Oxygenation, Oxygenation
Motivation: Cerebral venous oxygenation (Yv) is a potential biomarker in brain diseases. However, regional measurement of Yv in clinically desirable time (e.g., 1-2 minutes) is not available.
Goal(s): To develop a MR technique for rapid and accurate Yv measurement.
Approach: A EPI-based T2-Relaxation-Under-Phase-Contrast (TRUPC) MRI sequence was proposed. Eight subjects were studied to assess feasibility and reproducibility. Another eight underwent O2 inhalation and caffeine ingestion to demonstrate the sensitivity to Yv changes.
Results: The sequence can measure Yv in internal-cerebral-veins, straight-sinus, and superior-sagittal-sinus with a variability of 3%. It also showed excellent sensitivity to O2 and caffeine challenges.
Impact: We developed a MR technique for accurate and reliable Yv measurement on brain veins within 1.5 minutes. It showed nice reproducibility and consistency under different challenges with previously developed sequence.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords