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Abstract #0734

A straightforward approach for 3D single-shot ASL based brain perfusion imaging: preventing artifacts due to signal fluctuations

Dan Zhu1,2, Feng Xu1,2, Dapeng Liu1,2, and Qin Qin1,2
1F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 2The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling

Motivation: Inter-shot signal fluctuations could cause artifacts for multi-shot arterial spin labeling (ASL). 3D Stack-of-spirals (SOS) turbo FLASH (TFL) could easily achieve single-shot with moderate undersampling (R=3).

Goal(s): To evaluate the performance of 3D single-shot SOS-TFL acquisition pseudo-continuous ASL (PCASL) and velocity-selective ASL (VSASL), which eliminated the noticed artifacts.

Approach: On both simulation and 13 brain scans, 3-shot reconstruction was compared to 1-shot reconstruction with SENSE regularized with compressed sensing (CS-SENSE).

Results: Artifacts observed in 3-shot reconstruction were completely eliminated using the 1-shot reconstruction. The inferior part of the brain had higher signal fluctuations and more severe image artifacts.

Impact: This study showed that inter-shot signal fluctuations could cause artifacts for multi-shot arterial spin labeling, which were prevented using single-shot. Single-shot is recommended for all scans with potentially large signal fluctuations, which could be achieved with stack-of-spirals turbo FLASH acquisition.

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Keywords