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Abstract #0740

Comparison between multiparametric arterial spin labeling and 15O-water positron emission tomography in patients with moyamoya disease

Shota Ishida1,2, Hirohiko Kimura3,4, Makoto Isozaki5, Kenji Takata2, Yuki Matta2, Tetsuya Tsujikawa2, and Hidehiko Okazawa6
1Department of Radiological Technology, Faculty of Medical Sciences, Kyoto College of Medical Science, Kyoto, Japan, 2Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan, 3Faculty of Medical Sciences, University of Fukui, Fukui, Japan, 4Radiology Section, National Health Insurance Echizen-cho Ota Hospital, Fukui, Japan, 5Department of Neurosurgery, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan, 6Biomedical Imaging Research Center, University of Fukui, Fukui, Japan

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling

Motivation: Multiparametric arterial spin labeling (MP-ASL) may detect early-stage hemodynamic impairment in patients with moyamoya disease.

Goal(s): We aimed to evaluate the clinical relevance of MP-ASL in these patients.

Approach: We compared MP-ASL parameters with cerebrovascular reactivity (CVR) measured using 15O-water positron emission tomography.

Results: Arterial cerebral blood volume did not significantly correlate with CVR and showed no significant difference between the normal and reduced CVR groups. However, the residence time of labeled spins in the microvascular compartment significantly correlated with CVR and was prolonged in the reduced CVR group, suggesting its potential to differentiate between CVR conditions.

Impact: Multiparametric arterial spin labeling enables a detailed, noninvasive evaluation of cerebral hemodynamics in patients with moyamoya disease, with a clinically acceptable scan time, and potentially allows for the detection of early-stage hemodynamic impairment in these patients.

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Abstract Presentation Video

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