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Abstract #0753

Age-Related Alterations in Tissue Microstructure along perforant pathway of Hippocampus and the Tract Template Development

Yixin Ma1,2, Hansol Lee1,2, Kwok-Shing Chan1,2, Susie Y. Huang1,2, and Hong-Hsi Lee1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Aging, Aging, Hippocampus

Motivation: Quantifying microstructural alterations with age in the perforant pathway facilitates the understanding of mechanisms in aging and neurodegeneration.

Goal(s): We investigated age-related changes along perforant pathway of hippocampus and established a hippocampal tract template.

Approach: We acquired diffusion MRI (dMRI) data from 72 participants (19–85 year-old) on high-gradient performance Connectome MRI scanner. dMRI tract-based analysis revealed age-related alterations of diffusion metrics (DKI, SANDI) along perforant pathway.

Results: Along perforant pathway, FA decreased with age in WM, intra-neurite volume fraction decreased with age in WM and entorhinal cortex, and extracellular volume fraction decreased with age in dentate gyrus and entorhinal cortex (p<0.05).

Impact: We observed age-related alterations in tissue microstructure along the perforant pathway of hippocampus using high-gradient performance diffusion MRI. We built a hippocampal tract template using data of young subjects, offering a practical tool to investigate neurodegenerative diseases affecting hippocampal tracts.

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Keywords