Keywords: Aging, Aging, Hippocampus
Motivation: Quantifying microstructural alterations with age in the perforant pathway facilitates the understanding of mechanisms in aging and neurodegeneration.
Goal(s): We investigated age-related changes along perforant pathway of hippocampus and established a hippocampal tract template.
Approach: We acquired diffusion MRI (dMRI) data from 72 participants (19–85 year-old) on high-gradient performance Connectome MRI scanner. dMRI tract-based analysis revealed age-related alterations of diffusion metrics (DKI, SANDI) along perforant pathway.
Results: Along perforant pathway, FA decreased with age in WM, intra-neurite volume fraction decreased with age in WM and entorhinal cortex, and extracellular volume fraction decreased with age in dentate gyrus and entorhinal cortex (p<0.05).
Impact: We observed age-related alterations in tissue microstructure along the perforant pathway of hippocampus using high-gradient performance diffusion MRI. We built a hippocampal tract template using data of young subjects, offering a practical tool to investigate neurodegenerative diseases affecting hippocampal tracts.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords