Abstract #0764

Multi-center test-retest repeatability and reproducibility of in-vivo renal diffusion MRI measurements: preliminary findings

Siria Pasini¹, Leyre Garcia-Ruiz², Giulia Villa¹, Steffen Ringgaard³, Anika Strittmatter^4,5, Anish Raj^4,5, Rebeca Echeverria-Chasco², Verónica Aramendía-Vidaurreta², José María Mora Gutierrez⁶, Nuria García Fernández⁶, Michela Bozzetto¹, Paolo Brambilla⁷, Matias Trillini⁸, Lucian Itu⁹, Ioana Adriana Urdea⁹, Larisa Micu⁹, Niels Henrik Buus¹⁰, Malene Aastrup³, Esben Søvsø Szoc Hansen³, Susan Francis¹¹, Frank Zoellner^4,5, Christoffer Laustsen³, Maria Fernandez-Seara², and Anna Caroli¹

¹Bioengineering Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy, ²Department of Radiology, Clínica Universidad de Navarra, Pamplona, Spain, ³The MR Research Centre, Aarhus University, Aarhus, Denmark, ⁴Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ⁵Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ⁶Department of Nephrology, Clínica Universidad de Navarra, Pamplona, Spain, ⁷ASST Papa Giovanni XXIII, Bergamo, Italy, ⁸Department of Renal Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy, ⁹Advanta, Siemens, Brasov, Romania, ¹⁰Department of clinical medicine, Aarhus University, Aarhus, Denmark, ¹¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Diffusion Acquisition, Kidney

Motivation: As part of multi-parametric renal MRI, diffusion-weighted imaging (DWI) is a promising technique for the characterization of renal pathologies, however reliability of diffusion parameters is often hindered by lack of multi-center standardization.

Goal(s): To assess repeatability and reproducibility of DWI parameters.

Approach: 32 healthy volunteers were scanned in two sites using 3T MRI systems to assess kidney diffusion metrics (D,D*,F and ADC). Subjects were scanned twice on the same day for repeatability and after 7-14 days for reproducibility.

Results: All diffusion metrics were consistent across scans with D, D* and ADC showing excellent repeatability and reproducibility.

Impact: This study supports the reliability of diffusion-weighted imaging (DWI) in multi-center studies and demonstrates excellent repeatability and reproducibility of diffusion parameters.

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