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Abstract #0765

2D fitting improves simultaneous intravoxel incoherent motion (IVIM) and compartmental T2 mapping in the human kidney and liver

Julia Stabinska1,2, Thomas Thiel3, Alexandra Ljimani3, Hans-Jörg Wittsack3, and Helge J Zöllner1,2
1F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 2The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Department of Diagnostic and Interventional Radiology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

Synopsis

Keywords: IVIM, Body, IVIM, kidney, liver

Motivation: Pseudo-diffusion volume fraction f estimated by conventional IVIM model is biased due to its TR- and TE-dependence driven by differences in compartmental relaxation times.

Goal(s): To estimate TE-independent f values in the kidney and liver at 3T.

Approach: Numerical simulations and in vivo experiments were conducted to assess the effect of relaxation times on the IVIM parameter estimates when using the conventional IVIM and extended T2-IVIM models.

Results: The IVIM-based f estimates depend on selected TE and TR values. An increase in f with increasing TE was observed in the liver, whereas no clear trend was found in the kidney.

Impact: The extended 2D T2-IVIM model efficiently minimizes the bias in f values and allows simultaneous estimation of the IVIM parameter and compartmental T2 values in the liver and kidney.

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Keywords