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Abstract #0766

Evaluation of intravoxel incoherent motion (IVIM) to detect bone marrow ischemia and perfusion in a piglet model of Legg-Calvé-Perthes disease

Ashton A. Amann1, Erick O. Buko1,2, Suhail P. Parvaze1,2, Alexandra R. Armstrong1, Ferenc Tóth1, and Casey P. Johnson1,2
1Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, United States, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: IVIM, IVIM, Ischemia, Perfusion

Motivation: A safe, non-contrast-enhanced method to detect bone marrow ischemia and perfusion is needed for imaging children with ischemic bone disorders such as Legg-Calvé-Perthes disease (LCPD).

Goal(s): To determine if intravoxel incoherent motion (IVIM) is sensitive in detecting localized regions of bone marrow ischemia and perfusion within the femoral head.

Approach: 3T MRI data from N=4 piglets with partial (25-75%) femoral head ischemia were retrospectively analyzed to evaluate and compare IVIM parameters in ischemic vs. perfused regions of the femoral heads as identified by gadolinium contrast-enhanced MRI (CE-MRI).

Results: IVIM detected decreased perfusion parameters in the ischemic vs. perfused regions identified by CE-MRI.

Impact: Our results provide additional evidence that IVIM can serve as a non-contrast-enhanced alternative to gadolinium CE-MRI in detecting regions of bone marrow ischemia and perfusion, with potential benefit for pediatric patients with ischemic bone disorders including LCPD.

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