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Abstract #0767

The Value of Hybrid Multidimensional MRI in Identifying Prostate Cancer and Benign Prostatic Hyperplasia: A Feasibility Study

Hongyue Ji1, Hao Cheng1, Min Chen1, Xiaoguang Li1, Jinxia Zhu2, and Chunmei Li1
1Department of Radiology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P. R. China, Beijing, China, 2MR research collaboration,Siemens Healthineers, Beijing, China

Synopsis

Keywords: Microstructure, Prostate

Motivation: Distinguishing prostate cancer (PCa) from benign prostatic hyperplasia (BPH) can be challenging. Methods are needed to accurately and non-invasively assess tissue composition for differentiating the two.

Goal(s): We aimed to evaluate the feasibility of hybrid multidimensional (HM)-MRI to differentiate PCa from BPH.

Approach: We compared differences in tissue compositions on HM-MRI for PCa and BPH and evaluated the performance of HM-MRI in diagnosing PCa.

Results: Stromal, epithelial, and luminal volume fractions differed significantly between PCa and BPH. The area under the curve for differentiating PCa and BPH using epithelial volume fraction was 0.921. HM-MRI had high specificity for diagnosing PCa.

Impact: HM-MRI enables efficient and accurate identification of PCa and BPH, thereby providing reliable guidance for clinicians. HM-MRI also shows potential for other clinical applications.

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