Abstract #0770

Pulmonary MR angiography with gadopiclenol can reduce gadolinium exposure while maintaining signal enhancement.

Julius Frederik Heidenreich^1,2, Sheena Y Chu^1,3, Jan-Peter Grunz^1,2, Jitka Starekova¹, Prashant Nagpal¹, Scott B Reeder^1,3,4,5,6, and Thomas M Grist¹

¹Department of Radiology, University Madison Wisconsin, Madison, WI, United States, ²Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, ³Department of Medical Physics, University Madison Wisconsin, Madison, WI, United States, ⁴Department of Biomedical Engineering, University Madison Wisconsin, Madison, WI, United States, ⁵Department of Medicine, University Madison Wisconsin, Madison, WI, United States, ⁶Department of Emergency Medicine, University Madison Wisconsin, Madison, WI, United States

Synopsis

Keywords: Vascular/Vessel Wall, Contrast Agents

Motivation: Pulmonary magnetic resonance angiography (MRA) using gadolinium-based contrast agents (GBCAs) is an established method for exclusion of pulmonary embolism. The high relaxivity GBCA gadopiclenol presents an opportunity to reduce gadolinium exposure, potentially improving safety and sustainability of gadolinium-enhanced MRA.

Goal(s): To evaluate enhancement performance of 0.05 mmol/kg gadopiclenol for pulmonary MRA compared to 0.10 mmol/kg gadobenate dimeglumine.

Approach: Pulmonary MRA from 152 patients with gadopiclenol or gadobenate dimeglumine were evaluated retrospectively. Signal enhancement was analyzed quantitatively. Image quality was assessed qualitatively.

Results: Pulmonary arterial enhancement was significantly higher with gadopiclenol compared to gadobenate dimeglumine. Subjective image quality was equivalent.

Impact: The use of high relaxivity gadopiclenol can reduce gadolinium exposure by 50% while maintaining adequate contrast enhancement. This may improve the safety and sustainability of gadolinium-enhanced MRA.

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