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Abstract #0782

Serial Myocardial Fibrosis Assessments Predict Outcomes in Patients with Hypertrophic Cardiomyopathy: A Cardiac Magnetic Resonance Study

Yun Tang1 and Shihua Zhao1
1Department of Magnetic Resonance Imaging, Fuwai Hospital, National Center for Cardiovascular Diseases of China, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Synopsis

Keywords: Myocardium, Cardiomyopathy

Motivation: In the 2020 AHA/ACC guideline for patients with hypertrophic cardiomyopathy (HCM), repeat contrast-enhanced cardiac magnetic resonance (CMR) is recommended to evaluate late gadolinium enhancement (LGE) changes every 3-5 years for risk stratification.

Goal(s): To investigate the prognostic value of LGE assessed by serial CMR in HCM patients.

Approach: 313 consecutive patients with HCM who underwent two CMRs with long-term follow-up were retrospectively included.

Results: On the MaxStat analysis for primary and secondary endpoints, the optimal prognostic cut point was >1.50 and 3.75g/year, respectively. LGE mass progression was independently associated with the outcome and further improve the risk stratification.

Impact: In patients with hypertrophic cardiomyopathy, myocardial fibrosis increases over time. Judicious and serial assessments of late gadolinium enhancement on cardiac magnetic resonance can improve risk stratification and clinical decision-making to help patient management.

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