Keywords: Inflammation, Infiltration, Tissue Characterization
Motivation: Better way to assess myocardial histological changes in patients with myocarditis is desired.
Goal(s): Assess the utility of entropy, a novel measure of myocardial heterogeneity, for predicting cardiovascular events in patients with acute myocarditis.
Approach: Patients included were diagnosed with acute myocarditis by cardiac MRI or endomyocardial biopsy. Left ventricular entropy, scar entropy, LGE presence, LGE mass and LGE extent were derived.
Results: Entropy and scar entropy of patients in MACE group was significantly higher than that of No MACE group. Entropy maintained an independent association with MACE in a multivariable model including clinical presentation, left ventricular ejection fraction, and LGE extent.
Impact: LV entropy is a fully reproducible and highly prognostic measure of myocardial heterogeneity. It shows promising ability to predict adverse cardiovascular events in patients with acute myocarditis.
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